Surabhi Dangi-Garimella, PhD

Serious vascular events in patients with diabetes can be prevented with aspirin use, according to results of the ASCEND (A Study of Cardiovascular Events iN Diabetes) trial. The resuts were presented at the ongoing ESC Congress in Munich, Germany, and they were simultaneously published in

A substantial amount of evidence exists linking diabetes with heart disease, and The Framingham Heart Study was the first to show that patients with type 2 diabetes are more susceptible to heart disease. Aspirin use has, of course, been found to benefit patients with cardiovascular (CV) disease, and joint guidelines

developed by the American Heart Association and the American College of Cardiology Foundation recommend a 75- to 162-mg daily dose of aspirin in all patients with coronary artery disease.

However, the value of this antiinflammatory agent in preventing the first CV event in patients undergoing treatment for diabetes remains unknown.

The ASCEND trial was designed to randomly assign 15,480 adults with diabetes to receive 100 mg of aspirin daily, or a matching placebo. Trial participants did not have any hint of CV disease. Efficacy and safety were monitored and measured as the first serious vascular event (myocardial infarction, stroke, or transient ischemic attack; or death from any vascular cause, excluding any confirmed intracranial hemorrhage) and the first major bleeding event (intracranial hemorrhage, sight-threatening bleeding event in the eye, gastrointestinal bleeding, or other serious bleeding), respectively. Gastrointestinal (GI) tract cancers were monitored as secondary outcomes.

The ASCEND Study Collaborative Group. Effects of aspirin for primary prevention in persons with diabetes mellitus [published online August 26, 2018].

Smith SC Jr, Benjamin EJ, Bonow RO, et al. AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation endorsed by the World Heart Federation and the Preventive Cardiovascular Nurses Association. J Am Coll Cardiol. 2011;58(23):2432-2446. doi: 10.1016/j.jacc.2011.10.824. Erratum in:

. 2015;65(14):1495. Dosage error in article text.

Articles

A substantial amount of evidence exists linking diabetes with heart disease, and The Framingham Heart Study was the first to show that patients with type 2 diabetes are more susceptible to heart disease. 

Surabhi Dangi-Garimella, PhD

Articles

Study: Aspirin Confirmed for Prevention of Primary Vascular Events in Patients With Diabetes