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January 21, 2022 03:00pm
By Ashley Gallagher, Assistant Editor
Since the beginnings of modern medicine, experts have recognized a connection between diabetes and mental illness.
Since the beginnings of modern medicine, experts have recognized a connection between diabetes and mental illness. In the early 1800s, Thomas Willis, an English neurologist, speculated that diabetes was caused by “long sorrow and other depressions.”1About 70 years later, British psychiatrist Sir Henry Maudsley wrote in his bookThe Pathology of Mind, “Diabetes is a disease which often shows itself in families in which insanity prevails.”1More recently in the 1940s and 1950s, psychiatrists used insulin-coma therapy to treat patients with schizophrenia.2
Today, scientists understand a bidirectional relationship between psychiatric disorders and diabetes: each influences the other in a variety of ways. This article attempts to elucidate the prevalence of these often comorbid conditions and discuss the interface between diabetes and alcohol abuse, major depression, anxiety disorders, and schizophrenia, respectively.
Co-occurrence of Diabetes and Psychiatric Disorders
This presents in 5 different patterns1:
When diabetes and psychiatric conditions co-occur, treatment outcomes decline through impaired quality of life, reduced patient adherence, increased emergency room visits, higher rates of hospitalizations, and increased cost of care. A 2009 study found that the cost of care actually doubles in patients with co-occurring diabetes and mental health conditions compared with those who only have 1 of the 2 illnesses.3
Primary care providers are often unaware of the possible co-occurrence of psychiatric conditions in their diabetes patients. In fact, around 45% of psychiatric disorders go undiagnosed in patients treated for diabetes.4Experts recommend that clinicians screen all patients with diabetes for psychological distress using either the patient health questionnaire (PHQ) or other standardized assessment. The PHQ is a well-validated 9- or 15-question self-report questionnaire.5
Psychiatric disorders are typically diagnosed using theDiagnostic and Statistical Manual of Mental Disorders, 5th edition, and coded using the ICD-10.6Codes for psychiatric disorders are found in chapter F and categories 00-09.Table 16lists the categories of psychiatric disorders commonly seen co-occurring with diabetes.
About 50% to 60% of patients diagnosed with diabetes also consume alcohol.7Even when consumed safely, alcohol use increases a diabetic individual’s risk of hypoglycemia. Alcohol can impair an individual’s ability to recognize and respond effectively to a diabetic emergency, such as ketoacidosis. Both alcohol misuse and diabetes independently cause peripheral neuropathy and retinopathy, resulting in synergistic effects for both complications. Long-term alcohol use can lead to excessive weight gain further exasperating diabetes, as well.7
The CAGE questionnaire is a brief 4-question tool to help screen patients for problem drinking (Table 28). If patients answer “Yes” to more than one question, they should be referred to a substance abuse professional for a detailed evaluation. Primary care providers can offer the patient a referral and provide a brief intervention in the form of motivational interviewing, a patient-centered yet direct method for increasing intrinsic motivation by exploring and resolving patient ambivalence.9Primary care providers can use one simple MI tool in their practice: OARS (open-ended questions, affirming, reflective listening, and summarizing).9Remembering this acronym can help providers focus their therapeutic communication and encourage the patient to seek additional treatment.
Major Depressive Disorder
This is the most common psychiatric condition in patients with diabetes. In fact, its prevalence is 2 or 3 times higher in those with diabetes than in members of the general population.10Unfortunately, the exact relationship between these 2 conditions remains uncertain. Hyperglycemia worsens during periods of depression, and it actually exacerbates and prolongs any depressive state.1Moreover, long-term use of high-dose antidepressant medications doubles a patient’s risk of developing diabetes later in life.1
At each appointment, primary care providers should conduct a brief risk assessment using the PHQ-2 (Table 311). With this 2-question tool, clinicians can quickly determine the need for a mental health referral. A score greater than or equal to 3 indicates a need for further investigation, as well as a referral to a mental health professional, such as a psychiatric nurse practitioner or psychologist. Depending on the severity and type of depression, mental health professionals will likely use a combination of antidepressant medication and psychotherapy as treatment.11
The prevalence of these is higher in patients with diabetes than in members of the general population. The prevalence of generalized anxiety disorder, for example, is 3 times higher for those with diabetes.12Research has also demonstrated that symptoms of anxiety increase an individual’s risk of developing diabetes later in life. Needle-and-injection—related phobias, as well as a phobia of a hypoglycemic episode, are also sometimes found in patients with diabetes.13
To screen for generalized anxiety disorder, primary care providers can use the GAD-7 scale, a 7-item self-report questionnaire (Table 411). A score of greater than or equal to 10 indicates a possible diagnosis of generalized anxiety disorder and should be confirmed by a thorough evaluation. Phobias are characterized by a persistent, disproportional fear of a specific object or situation such as needles or a hypoglycemic episode.2Psychological treatments for anxiety disorders are extremely effective; therefore, a referral to a mental health clinician will likely substantially improve the patient’s quality of life.2
For those with schizophrenia, the risk of developing diabetes is 4 times greater than for members of the general population.14Individuals with comorbid schizophrenia and diabetes have higher mortality rates than those who only have one condition, and a family history of diabetes is more common in those with schizophrenia than those without.14
Research reveals that both genetic and environmental factors contribute to the high rate of impaired glucose tolerance in patients diagnosed with schizophrenia.1Inactivity, poor nutrition, and treatment with antipsychotic medications increase the risk of developing diabetes later in life.1Clozapine and olanzapine are most likely to cause metabolic syndrome, followed by risperidone and quetiapine.2There is also some evidence suggesting that schizophrenia is an independent risk factor for diabetes.1
Managing patients with both a psychotic disorder and diabetes requires expert care coordination between primary care and mental health providers.2Primary care clinicians should recommend psychological approaches that will help their patients understand and remain adherent to their diabetes treatment plans. Maintaining close contact with the patients’ case managers and reinforcing self-management strategies at each appointment can help improve this population’s outcomes.
Referral to a Mental Health Professional
This may make a patient feel stigmatized or “crazy.” Even patients who are interested in professional counseling face significant barriers including cost and time commitment. The most successful referrals occur within a trusting and established patient-provider relationship.
Knowing when to refer a patient with diabetes can also be difficult. Referrals can be made for a psychiatric nurse practitioner who specializes in psychotropic medication management or for a psychologist with advanced training in a particular form of psychotherapy, such as motivational interviewing or cognitive-behavioral therapy. Referrals to psychiatric specialists should almost always be provided in the following cases:
The interface between diabetes and psychiatric disorders is complex and not completely understood. This comorbidity often increases the risk of poor patient outcomes; however, when primary care providers and psychiatric specialists work together, these individuals can receive effective and comprehensive treatment.
Dr. Melissa DeCapua is a board-certified psychiatric nurse practitioner. She currently works as a consultant for small health care technology companies, and she recently won the Seattle Health Innovator award. Dr. DeCapua is a strong advocate for empowering nurses, and she fiercely believes that nurses should play a pivotal role in shaping modern health care. For more about Dr. DeCapua, visit her website atmelissadecapua.comand follow her on Twitter@melissadecapua.